Shanghai Jiao Tong University professor discovers "obesity bacteria"

New discovery of the causes of obesity: Enterobacter cloacae intestinal bacteria are one of the direct culprits in obesity

This achievement was proved by laboratory experiments led by Professor Zhao Liping of Shanghai Jiaotong University and was published in the ISME Journal, the top academic journal in the international field of microbial ecology, published on December 13.

In experiments, Enterobacter cloacae, an intestinal bacterium from obese patients, caused severe obesity and insulin resistance in sterile mice, which provided the most direct experimental evidence for the intestinal flora's participation in the occurrence and development of obesity and diabetes in humans. The "intestinal origin theory" provides the most direct experimental evidence.

Zhao Liping said that the Enterobacter cloacae found in the laboratory he is responsible for can produce endotoxin, which can cause sterile mice that originally eat high-fat diet but not gain weight to develop severe obesity, and can also cause inflammation and insulin resistance in mice., it can also turn off genes needed to consume fat and activate genes that synthesize fat. It is a bacterium that has been sought internationally to cause obesity.

In clinical studies, researchers found that Enterobacter cloacae, a pathogenic bacterium that can produce endotoxin, overgrew in the intestines of an obese patient weighing 175 kilograms, accounting for one-third of the total bacterial count. After intervention with a specially designed nutritional formula, the number of the bacteria quickly dropped to undetectable levels. The patient's weight dropped by 51.4 kilograms in nearly six months, and symptoms such as hyperglycemia, hypertension and hyperlipidemia returned to normal.

There are about 1000 kinds of bacteria living in the human intestine, collectively called intestinal flora. Their total weight is about 1.5 kilograms, and their total number of cells is 10 times that of the human body's own cells.

Tradition believes that obesity is mainly caused by four major causes.

1. Genetic factors.

Most of them are identified as "multi-factor inheritance". When a parent's constitution is passed on to their children, it is not one genetic factor, but a majority of genetic factors that determine the child's constitution. Therefore, it is called multi-factor inheritance, such as non-insulin-dependent diabetes and obesity belong to this type of inheritance. If one parent is obese, the child has a 40% chance of being obese. If both parents are obese, the child's chance of being obese rises to 70%-80%. There are few examples of "multi-factor inheritance", and there are many examples of people inheriting their parents '"wrong eating habits" and leading to obesity.

2. factors of the social environment.

Many people have the concept that "being able to eat is a blessing". In today's society, there are many kinds of food, and all kinds of delicious food often tempts you. In addition,"eating a big meal" has almost become a common entertainment, which of course has become the main cause of obesity.

3. Psychological factors.

In order to relieve emotional troubles and emotional instability, many people also use "eating" to vent. These are all causes of overeating and obesity.

4. Factors related to exercise.

Exercise helps to consume fat. In daily life, with the development of transportation, mechanization of work, and reduction in housework, the body has fewer opportunities to consume calories. On the other hand, because the energy intake has not decreased, it forms obesity. Fat leads to slower and lazier daily activities, and once again reduces calorie consumption, leading to a vicious cycle that promotes the occurrence of obesity.

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