Want to lose weight and see what the intestinal bacteria say?

A new study from researchers at Chalmers University of Technology may guide our dietary choices based on the body's gut microorganisms, which is important for effective weight loss and disease risk reduction. Related research was published in the international journal Cell Metabolism. For the first time, the study successfully revealed the molecular mechanisms of common gut bacterial interactions during metabolism.

In the article, researchers have developed a new mathematical computing platform that can help predict the response of different patients to a modified diet based on the composition of their body's intestinal microbiome. Researcher Dr. Jens Nielsen said that this method may help us easily identify the metabolic mechanisms of each bacterial type and help understand the metabolic mechanisms of the human body. There are more than 1000 different types of bacteria and other microbial communities in the human digestive system, many of which metabolize in one or more ways, and the composition of the human intestinal microbiome will vary from individual to individual. The reason is not clear to researchers at present. However, many studies conducted by researchers over the past years have shown that there is a inextricable relationship between certain diseases and the human gut microbiome.

For example, type 2 diabetes, arteriosclerosis and obesity are all related to the intestinal microbiome, and studies have shown that the intestinal microbiome may also be directly related to the incidence of depression, and of course it may also respond to the response to various cancer therapies. Clarifying the relationship between microorganisms and food and individual diet is very complex. So far, it has been difficult for researchers to understand the causal relationship between these factors. However, in this study, researchers used mathematical models for the first time through clinical trials to clarify the relationship between microbial communities and diet patterns.

The starting point of the study is the diet test conducted by the researchers. First, the intestinal microbiome is mainly reflected in the physical characteristics of a single individual in overweight patients. Secondly, when patients undergo a weight-loss diet, everyone will lose weight; However, in patients with low intestinal microbiome diversity, the content of multiple substances indicating health risks may be reduced in the blood and feces of individuals; Jens Nielsen believes that this study can easily identify which overweight patients are at risk of high-risk myocardial metabolic disease, and can also help modify patients 'diets and lose weight to help improve their health outcomes.

In the long run, we should increase the intestinal flora of patients whose metabolic functions are inappropriate. Probiotics are a good choice, such as eating a variety of yoghurts. However, the main role of probiotics is to stabilize the intestines and create an environment suitable for the growth of intestinal flora; and the new generation of probiotics will add more beneficial flora to the patient's intestines, thereby helping to improve the patient's intestinal health.